What Is the Crawford / Alexander Link?

As I was transcribing deeds from Jefferson County, Indiana, I found a connection with a guardian record. In the deed, Isaac Crawford sold land to Thomas Alexander. In the guardian record, Thomas Alexander is reimbursed for expenses as a guardian of an orphan on Isaac Crawford. So, what is the connection between Thomas Alexander and Isaac Crawford?

Jefferson County Indiana
Court Records

image 612 - C Index
Crawford M all to Alexander 085
Crawford M settlement 087
Crawford J alld Alexander 85
Crawford M settlement 87

Probate Order Book v. C, Feb. 1827-June 1830
Family Search Film 1310225 Items 3-5; DGS 7663707

183? - actual date not found

Ordered that Thomas Alexander be allwd sixty four dollars
and eighty cents for keeping Isaac Crawford an
Infant orphan of Isaac ^Crawford [Or] take credit on
a note by the adm of P. Crawford [RC]

Jefferson County Indiana Deeds

Book E page 452 Image 239
Family Search Film 1310268 DGS 8059613

page 453

This Indenture, made this nineteenth day of November in the year of
our Lord, one thousand eight hundred and twenty two between
Isaac Crawford & Nancy his wife of Jefferson County [and state]
of Indiana of the first part, and Thomas Alexander of the
same County of the second part witneseth that the said
Isaac Crawford & Nancy his wife for and in consideration
of the sum of eight hundred dollars lawful money [?]
United States to them in hand well and truly paid [?]

page 454

Thomas Alexander the receipt whereof is hereby acknowledged,
have granted, bargained, sold, aliened, released, conveyed and
Confirmed, and by these presents do grant, bargain, sell,
alien, release, convey and confirm, unto the said Thomas Alexander
his heirs and assigns forever, all that certain tract of land
lying & being situated in the County of Jefferson & State of
Indiana, and known by the south east quarter of section no.
seventeen of township no. four north in range ten east in 
the district of lands offered for sale at Jeffersonville - Reserv
ing & excepting out of this conveyance twenty five acres off the
south side of said quarter which the said Isaac Crawford here
to fore sold & conveyed to one Gillum Hudson as will more
fully appear by refference to the records of said conveyance
in the recorders office of said county — And all the estate,
right, title, interest, claim and demand of them the said Isaac
Crawford & Nancy his wife of, in and to the said premises, and
every part thereof, Together with all and singular the priveleges
and appertuances to the same belonging or in any wise app
ertaining and the rents, issues and profits thereof, to have and
to hold the premises hereby bargained and sol, or means, or 
intended so to be, with the appertenances, to the only proper 
use and behoof of the said Thomas Alexander his heirs and
assigns forever and the said Isaac Crawford & Nancy his
wife their heirs, executors and administrators, do covenant prom
ise and agree to and with the said Thomas Alexander his heirs,
executors, administrators and assigns that they are the true and
lawful owners of the premises hereby granted and have
good right full power and lawful authority to all
and convey the same in manner and form aforesaid and
further that they the said Isaac Crawford & Nancy his
wife their heirs executors and administrators, will warrante
and forever defend the aforesaid premises, with their apperten
ances, and every part and parcel thereof unto the said
Thomas Alexander his heirs and assigns against all persons
claiming and claim by, from or under them or any of them
or by from or under any other person or persons who[ud]soever
[be] witness whereof the said Isaac Crawford & Nancy his 
wife have hereunto set their hands and seals the day 
& man first above written
Isaac Crawford (seal)
Nancy (her mark) Crawford (seal)
Sealed and delivered
in the presence of
[N?] Palmer
O. E. Hough